We report a case of an acute ST-segment elevation myocardial infarction in a affected person with traditional cardiac threat elements using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient additionally had polycythemia, probably secondary to high-dose testosterone. The affected person underwent profitable percutaneous intervention of the best coronary artery. Physicians and patients should be conscious of the scientific consequences of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a part of endothelial dysfunction has been proposed, which can contribute to irregular vessel reactivity.
- Men with coronary artery illness have decrease ranges of androgens than males with normal coronary angiograms.
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However, testosterone in physiologic doses might even be beneficial in patients with angina , have greater ischemic thresholds and improved quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and increases coronary blood move in males with established coronary artery disease . Therefore, an interplay of endogenous factors of the patient’s danger profile in addition to the testosterone dosing may be issues of whether or not adverse occasions happen. Erythrocytosis has been reported as a potential impact of testosterone, which could be beneficial in patients with anemia.
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Patients additionally could additionally be taking concomitant stimulants, corresponding to ephedra, which might confound knowledge and the potential for opposed occasions. It is likely that the frequency of cardiac events is underreported within the medical literature. Moreover, testosterone has been used in the therapy of reduced muscle mass and bone density as nicely as anemia. The role testosterone could play in the growth of cardiovascular disease has more and more turn out to be the topic of current interest . Supraphysiologic doses of anabolic-androgenic steroids , which embrace more than 30 natural and artificial derivatives of testosterone, may cause a wide spectrum of medical sequalae. Supplemental or physiologic doses of testosterone have noticed expanded use in medical follow just lately. Other common potential antagonistic results include infertility, hepatotoxicity, psychological abnormalities, and gynecomastia .
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