The ultimate adaptation about ratio regarding CO and GC situations observed with each other chromosomes making use of negative dating ranging from CO and you may GC cost hence appear to be contradictory toward “depending design” if you’re help an even more vibrant one to associated with a variable DSB fix path otherwise DHJ solution around the genomes
It is extremely interesting to see that the noticed designs out-of CO and you may GC shipping collectively chromosomes is also tell us regarding the activities proposed to explain chiasma interference. New “counting model” takes on you to double-string holiday breaks are present on their own, hence a predetermined and you may system-certain count (m) from noncrossovers (GC occurrences) are present ranging single Sex Sites dating from neighboring crossovers , . A later extension of model incorporated the potential for an effective fraction away from meiotic crossovers regarding the another path which is maybe not at the mercy of interference .
At a 100-kb scale, we have shown that CO, and to a much lesser degree GC, are not randomly distributed across chromosomes. five hundred and GC500; see above). We found that the distribution of CO and GC events is not random in terms of intergenic/genic sequences, with a significant tendency to be located within genic sequences (P<0.00001, Figure 10A; see Materials and Methods for details). Continue reading →